Prostat kanseri DNA verilerinin atılan kısmında yeni bakteriler bulundu

Researchers at the University of East Anglia have reconstructed the genomes of 18 new bacterial species using DNA data from men with prostate cancer. When tumour or blood samples are sequenced, a small share of the reads does not belong to human DNA and is usually discarded as noise. The team kept these fragments instead and, through a method called metagenomic assembly, rebuilt 249 nearly complete bacterial genomes from 194 patients, screening 2,176 datasets gathered by the international Pan Prostate Cancer Group for other research purposes. No extra samples had to be collected. Most of the microbes are oral organisms, and Porphyromonas, the group containing the chief microbe behind gum disease, turned up most often. The researchers stress that they are not claiming these organisms cause cancer. Rather, the genomes, predicted growth conditions and a validated DNA test for one species give scientists tools to examine, one species at a time, whether any of them is linked to aggressive disease.